Arizona at New England (-13.5)
Analysis: The Patriots will face yet another backup quarterback as they did virtually the entire second half of last year. This could be Kevin Kolb’s last stand. Ty Cobb has a better chance of winning on Sunday. Patriots.
Baltimore at Philadelphia (-1)
Analysis: The Ravens had a major letdown off a Week 1 divisional drubbing a year ago, while the Eagles avoided a disaster in Cleveland. The Ravens need to run the ball effectively to neutralize the Philly blitz. This one will be close but Baltimore should prevail. Ravens.
Cleveland at Cincinnati (-7)
Analysis: The Browns rarely win division games (they are a combined 14-46 vs. the AFC North since 2002), so an upset isn’t likely, and Brandon Weeden threw four picks last week. Cincy is better than their Week 1 performance would indicate. Bengals.
Houston (-7) at Jacksonville
Analysis: An AFC Super Bowl contender, Houston got off to a flying start albeit against woeful Miami. Now they get another sadsack team from the Sunshine State coming off a heartbreaking loss. Jacksonville’s spirits are crushed, and the few fans in attendance will see it first-hand. Texans.
Kansas City at Buffalo (-3.5)
Analysis: The Bills were a chic surprise pick and a chic upset pick last week, but they played like chicks. Fred Jackson’s injury is bigger than people think. Matt Cassel needs to step it up, but Jamaal Charles could be the difference maker here. Chiefs.
Minnesota (-1.5) at Indianapolis
Analysis: Andrew Luck had a tough go of it against the Bears in his debut but should find things easier against Minnesota. Christian Ponder rallied the Vikes against the Jags, and Adrian Peterson was strong in his return, but Indy should get the win. Colts.
New Orleans (-2.5) at Carolina
Analysis: No Sean Payton is a bigger deal than it appears. So is the loss of Carl Nicks on the offensive line. Can the Panthers expose the Saints defense the way the Skins did? Cam Newton only put up 10 last week, so odds are, no dice. Saints.
Oakland (-1) at Miami
Analysis: Once a glorified rivalry, now a flush short of the Toilet Bowl. The Dolphins could be in for a long year with Ryan Tannehill, but Oakland is in for a long year every year. 14 minutes without a penalty? Almost had us fooled, guys. Dolphins.
Tampa Bay at New York Giants (-7)
Analysis: Giants will have extra time to get ready for this one after a drubbing at the hands of Dallas, and Tampa Bay may have used up some early luck last week for Greg Schiano. The Giants are at their best when their backs are against the wall. In New York and playing for Tom Coughlin at 0-1, they are dangerous. Giants.
Dallas (-3) at Seattle
Analysis: The Cowboys are flying high and well-rested after offing the Giants in the opener, and now they get to rattle a rookie quarterback in Russell Wilson. As long as they contain Marshawn Lynch, they’ll be fine. Cowboys
Washington (-3) at St. Louis
Analysis: What will RG3 do for an encore? Well, the Rams defense is better than the Saints’, so it might be somewhat subdued. Meanwhile, the Rams lost a heartbreaker last week and look much improved and could have an upset in store for the Skins. Rams
New York Jets at Pittsburgh (-5)
Analysis: Mark Sanchez and the Jets really put up 48 points last week? The Steelers gave up 31? Believe both. Now the Jets take their circus act to Pittsburgh seeking some AFC title game revenge. The aging and banged-up Steleers haven’t been 0-2 since 2002 but could be ripe for the picking with some key injuries. Darrell Revis’ status is up in the air, but theJets’ key to victory will be containing Big Ben. Odds are they will. Jets
Tennessee at San Diego (-6)
Analysis: With Jake Locker possibly out and the Chargers defense feeling good after Monday’s strong performance, the Chargers could roll in this one. Chargers
Detroit at San Francisco (-7)
Analysis: The Handshake Part 2 – this should be fun. Lions were lucky to get a win last week, while the 49ers were as impressive as any team in the league. The Lions likely won’t have enough balance of a run game to keep the San Francisco defense off Matthew Stafford. 49ers
Denver at Atlanta (-3)
Analysis: The Falcons put up 40 points on a solid Chiefs defense last week and now take on Peyton Manning coming off an emotional win. It might be hard to match that emotion and also for the Broncos to match the Falcons score for score. Falcons
UPSET OF THE WEEK JETS OVER STEELERS